How inflammaging influences your risk for age-related diseases
By David G. Watumull, co-founder and chairman, Lokahi Longevity
“Hawaii holds a special place in longevity science, notably through groundbreaking research on the FOXO3 longevity gene. Studies conducted here and validated globally in multiple ethnic populations show individuals with certain active FOXO3 gene variants are three times more likely to live healthily to age 100. Interestingly, this longevity gene helps regulate inflammation, linking genetic longevity directly to inflammaging. At Lokahi, FOXO3 testing forms a critical component of our diagnostic suite.”
In my first post in this series, I introduced you to inflammaging—the persistent, low-grade inflammation that quietly shapes our aging process. Today, I'd like to explain how inflammaging affects your health and why it’s become such an important focus for longevity medicine.
When we discuss chronic inflammation, we’re talking about something more subtle than the familiar redness and swelling from a temporary injury. Chronic inflammation quietly alters the body’s internal environment, silently contributing to many of the most common diseases associated with aging.
Chronic inflammation and cardiovascular disease
One of the most significant diseases linked to inflammaging is cardiovascular disease. Inflammation contributes to the buildup of plaques within artery walls. These plaques don’t simply narrow arteries—they can rupture, leading to heart attacks or strokes.
Recent studies have identified elevated inflammatory biomarkers—like high-sensitivity C-reactive protein (hs-CRP)—as powerful predictors of heart disease. Research even shows that lowering inflammation can reduce heart attack risks independently from cholesterol levels, underscoring inflammation’s central role in heart health.
Inflammation’s link to cognitive decline
Another major health concern influenced by inflammaging is cognitive decline and Alzheimer's disease. Over time, chronic inflammation affects brain cells and their ability to communicate effectively. Studies consistently find elevated inflammatory markers in individuals experiencing cognitive decline, suggesting inflammation accelerates memory loss and cognitive dysfunction.
At Lokahi Longevity, we emphasize early detection of these markers, allowing interventions to begin before noticeable symptoms emerge. Addressing inflammation early may protect cognitive function, preserving both mental clarity and independence well into old age.
Osteoarthritis, rheumatoid arthritis, and inflammaging—more than just joint pain
Osteoarthritis, often dismissed as simply "wear and tear," also has a clear inflammatory component. Chronic inflammation contributes to joint tissue breakdown, making movement increasingly difficult and painful. Research indicates that controlling systemic inflammation can significantly alleviate osteoarthritis symptoms and enhance joint health.
Inflammation is a key characteristic and a central mechanism in rheumatoid arthritis (RA), an autoimmune disease where the body's immune system mistakenly attacks the synovial membrane (lining) of the joints, causing inflammation. This inflammation leads to pain, swelling, stiffness, and potential joint damage.
At Lokahi, our personalized longevity protocol often includes specific anti-inflammatory dietary advice, targeted supplements, and evidence-based lifestyle practices aimed at preserving joint health and mobility.
Inflammation and metabolic diseases: Diabetes and beyond
Inflammaging also shapes the trajectory of metabolic diseases such as type 2 diabetes. Inflammation can reduce insulin sensitivity, which gradually leads to impaired glucose metabolism and eventually diabetes. Ongoing studies reveal that lowering chronic inflammation improves metabolic health and reduces diabetes risk—further highlighting inflammaging’s extensive role in overall health.
Cancer and chronic inflammation
Finally, chronic inflammation also contributes to certain types of cancers by promoting a cellular environment that supports cancer cell growth and spread. Research demonstrates that long-term inflammation significantly increases risks for several cancers, including colon, breast, and prostate cancers. Early detection and proactive inflammation management can dramatically reduce cancer risk, reinforcing our mission to detect and control inflammation early.
Hawaii-based insights: The FOXO3 longevity gene
Hawaii holds a special place in longevity science, notably through groundbreaking research on the FOXO3 longevity gene. Studies conducted here and validated globally in multiple ethnic populations show individuals with certain active FOXO3 gene variants are three times more likely to live healthily to age 100. Interestingly, this longevity gene helps regulate inflammation, linking genetic longevity directly to inflammaging. At Lokahi, FOXO3 testing forms a critical component of our diagnostic suite.
What it means for you
Clearly, inflammaging isn't merely an abstract idea—it's a core driver behind many diseases that shape the aging process. Understanding and managing this chronic inflammation represents a powerful strategy for achieving a healthier, longer life.
In my next post, we'll explore the advanced diagnostics we use at Lokahi Longevity to identify and measure your personal inflammaging profile. Understanding your inflammation status is the first step toward meaningful intervention.
Stay tuned and stay healthy!
